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Arginase 1 antibody [ARG1/1125]

Anti-Arginase 1 antibody [ARG1/1125] used in Western Blot (WB). GTX34415
Anti-Arginase 1 antibody [ARG1/1125] used in IHC (Paraffin sections) (IHC-P). GTX34415
Anti-Arginase 1 antibody [ARG1/1125] used in Protein Array (Protein Array). GTX34415

Cat. No. GTX34415

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 ARG1/1125

Isotype

 IgG3

Application

 WB, IHC-P, Protein Array

Reactivity

 Human, Mouse
Package
100 μg ($529)
See all Arginase 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-2μg/ml
IHC-P 2-4μg/ml for 30 minutes at RT
Protein Array Assay dependent

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

35 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human ARG1 protein fragment (around aa11-97) (exact sequence is proprietary)

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ARG1 , arginase 1 , Arginase 1 , Liver Arginase , Arginase I

Cellular Localization

Cytoplasm

Background

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Database

Research Area

DATA IMAGES

Anti-Arginase 1 antibody [ARG1/1125] used in Western Blot (WB). GTX34415

GTX34415 WB Image

WB analysis of (A) recombinant ARG1 Protein Fragment (B) human liver lysates using GTX34415 Arginase 1 antibody [ARG1/1125].

Anti-Arginase 1 antibody [ARG1/1125] used in IHC (Paraffin sections) (IHC-P). GTX34415

GTX34415 IHC-P Image

IHC-P analysis of human hepatocellular carcinoma tissue using GTX34415 Arginase 1 antibody [ARG1/1125].

Anti-Arginase 1 antibody [ARG1/1125] used in Protein Array (Protein Array). GTX34415

GTX34415 Protein Array Image

Analysis of Protein Array containing more than 19,000 full-length human proteins using Arginase-1 Mouse Monoclonal Antibody (ARG1/1125). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

REFERENCE

Application Reference

Tzeng H.T. et al. Cancers 2021; 13 (6) : 1253 Plasminogen Activator Inhibitor-1 Secretion by Autophagy Contributes to Melanoma Resistance to Chemotherapy through Tumor Microenvironment Modulation.
Application : IHC-P
Reactivity : Mouse
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529