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Aurora A antibody

Anti-Aurora A antibody used in Immunoprecipitation (IP). GTX21287
Anti-Aurora A antibody used in IHC (Paraffin sections) (IHC-P). GTX21287

Cat. No. GTX21287

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P, IP

Reactivity

 Human
Package
50 μg ($399)
See all Aurora A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent
IP 2-10μg antibody/mg lysate
Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Product Note

The epitope maps to a region between residues 50-100 of human Aurora kinase A.

Predict Reactivity

Chimpanzee, Northern white-cheeked gibbon, crab-eating macaque(>80% identity)

PROPERTIES

Form

Liquid

Buffer

Tris-Citrate/Phosphate

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide representing a portion of the protein encoded within exon 5.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_367504

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

AIK , ARK1 , AURA , AURKA , BTAK , PPP1R47 , STK15 , STK6 , STK7 , aurora kinase A , Aurora A , ARK-1

Cellular Localization

Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Spindle pole,Cilium basal body,Centriole

Background

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Aurora A antibody used in Immunoprecipitation (IP). GTX21287

GTX21287 IP Image

IP analysis of 35S-Met-labeled whole cell lysate transfected with a human Aurora A expression construct using GTX21287 Aurora A antibody.
IP reaction : 2-10μg/mg lysate

Anti-Aurora A antibody used in IHC (Paraffin sections) (IHC-P). GTX21287

GTX21287 IHC-P Image

The data was published in the journal Sci Rep in 2017. PMID: 28102366

REFERENCE

Application Reference

Mobley A et al. Sci Rep 2017; 7 : 40714 Aurora Kinase A is a Biomarker for Bladder Cancer Detection and Contributes to its Aggressive Behavior.
Application : IHC-P
Reactivity : Human
Submit a Reference

REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399