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Bcl-XL antibody [HL2038]

Recombinant antibody Orthogonal
Anti-Bcl-XL antibody [HL2038] used in Western Blot (WB). GTX637939
Anti-Bcl-XL antibody [HL2038] used in Western Blot (WB). GTX637939
Anti-Bcl-XL antibody [HL2038] used in Western Blot (WB). GTX637939
Anti-Bcl-XL antibody [HL2038] used in IHC (Paraffin sections) (IHC-P). GTX637939
Anti-Bcl-XL antibody [HL2038] used in IHC (Paraffin sections) (IHC-P). GTX637939

Cat. No. GTX637939

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 HL2038

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat, Cat, Dog
Package
100 μl ($399),
25 μl ($169)
See all Bcl-XL products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

26 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment of human Bcl-XL

Purification

Affinity purified by Protein A.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BCL2 like 1 , BCL-XL/S , BCL2L , BCLX , Bcl-X , PPP1R52

Cellular Localization

Mitochondrion outer membrane,Mitochondrion matrix,Cytoplasm, cytosol,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,Nucleus membrane

Background

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]

Database

Research Area

DATA IMAGES

Anti-Bcl-XL antibody [HL2038] used in Western Blot (WB). GTX637939

GTX637939 WB Image

Orthogonal

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-XL antibody [HL2038] (GTX637939) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.

Anti-Bcl-XL antibody [HL2038] used in Western Blot (WB). GTX637939

GTX637939 WB Image

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-XL antibody [HL2038] (GTX637939) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Bcl-XL antibody [HL2038] used in Western Blot (WB). GTX637939

GTX637939 WB Image

Rat tissue extract (50 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-XL antibody [HL2038] (GTX637939) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Bcl-XL antibody [HL2038] used in IHC (Paraffin sections) (IHC-P). GTX637939

GTX637939 IHC-P Image

Bcl-XL antibody [HL2038] detects Bcl-XL protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse intestine.
Bcl-XL stained by Bcl-XL antibody [HL2038] (GTX637939) diluted at 1:100.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Bcl-XL antibody [HL2038] used in IHC (Paraffin sections) (IHC-P). GTX637939

GTX637939 IHC-P Image

Bcl-XL antibody [HL2038] detects Bcl-XL protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded cat intestine.
Bcl-XL stained by Bcl-XL antibody [HL2038] (GTX637939) diluted at 1:100.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

REFERENCE

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REVIEW

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Package List Price ($)
$ 399
$ 169
Custom Conjugations