APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 μg/mL |
| 5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Breast Tissue Lysate(GTX24006) , Human Breast Tissue Slide(GTX24324)
Product Note
This antibody is specific for CCDC98 N-Terminus
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
CCDC98 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human CCDC98.The immunogen is located within amino acids 80 - 130 of CCDC98.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
abraxas 1, BRCA1 A complex subunit , ABRA1 , CCDC98 , FAM175A
Cellular Localization
Nucleus
Background
CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
Database
Research Area
DATA IMAGES
|
GTX85433 WB Image
WB analysis of human breast tissue lysate in (A) the absence and (B) presence of blocking peptide using GTX85433 CCDC98 antibody.
Working concentration : 1 μg/ml
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GTX85433 IHC-P Image
IHC-P analysis of human breast tissue using GTX85433 CCDC98 antibody.
Working concentration : 5 μg/ml
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REFERENCE
There are currently no references for CCDC98 antibody (GTX85433). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CCDC98 antibody (GTX85433). Be the first to share your experience with this product.
