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CCR3 antibody

Anti-CCR3 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX21667

Cat. No. GTX21667

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, ELISA, IHC

Reactivity

 Human
Package
100 μg ($399)
See all CCR3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
ICC/IF Assay dependent
ELISA 1:30,000
IHC 1:300
Not tested in other applications.

Calculated MW

41 kDa. ( Note )

Product Note

Peptide sequence is < 50 % identical to other human chemokine receptors in this region.

PROPERTIES

Form

Liquid

Buffer

10mM KHPO₄, 140mM NaCl, 0.1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

C-VETFGTTSYYDDVGLLCEKADTRALMA 28 amino acid synthetized corresponding to aa 8-34 (cysteine added for coupling) of the N-terminal domain of human CCR3

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CC motif chemokine receptor 3,CCCKR3,CCR3,CD193,CKR3,CMKBR3,C-C motif chemokine receptor 3

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Database

Research Area

DATA IMAGES

Anti-CCR3 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX21667

GTX21667 ICC/IF Image

ICC/IF analysis of human peripheral blood cells using GTX21667 CCR3 antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 399