GeneTex

  • Country / Location Selection

United States (US)

CD11b antibody [MEM-170] (Azide Free)

Anti-CD11b antibody [MEM-170] (Azide Free) used in Flow cytometry (FACS). GTX79994

Cat. No. GTX79994

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MEM-170

Isotype

 IgG1

Application

 FACS, Functional Assay

Reactivity

 Human
Package
100 μg ($399)
See all CD11b products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Functional Assay Assay dependent
Not tested in other applications.

Calculated MW

127 kDa. ( Note )

Product Note

This antibody recognizes CD11b antigen (Mac-1alpha), a 165-170 kDa transmembrane protein type 1 mainly expressed on monocytes, granulocytes and NK-cells. The antibody blocks (not completely) Mac-1-mediated neutrophil binding to fibrinogen.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human granulocytes

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_11179298

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD11B , CR3A , ITGAM , MAC1 , MAC1A , MO1A , SLEB6 , integrin subunit alpha M , CD11b , Mac-1 , Macrophage 1 antigen

Cellular Localization

Cell membrane,Membrane raft

Background

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Database

Research Area

DATA IMAGES

Anti-CD11b antibody [MEM-170] (Azide Free) used in Flow cytometry (FACS). GTX79994

GTX79994 FACS Image

FACS analysis of human peripheral blood using GTX79994 CD11b antibody [MEM-170] (Azide Free).

REFERENCE

There are currently no references for CD11b antibody [MEM-170] (Azide Free) (GTX79994). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for CD11b antibody [MEM-170] (Azide Free) (GTX79994). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Package List Price ($)
$ 399
Custom Conjugations