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CD11c antibody [N418]

Cat. No. GTX74940

Reference 13

Host

 Armenian Hamster

Clonality

 Monoclonal

Clone Name

 N418

Isotype

 IgG2

Application

 ICC/IF, IHC-P, IHC-Fr, FACS, IP, Neutralizing/Inhibition

Reactivity

 Mouse
Package
100 μg ($339)
See all CD11c products
PRODUCT

Summary

The N418 antibody reacts with mouse CD11c, also known as integrin αalpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha X (CD11c) assembles with integrin αbeta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

129 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Mouse spleen dendritic cells.

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_378302

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin alpha X , AI449405 , Cd11c , Cr4 , N418

Cellular Localization

Membrane

Database

Research Area

REFERENCE

Application Reference

Morita TY et al. Nat Commun 2023; 14 (1) : 7490 CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade.
Tong L et al. Sci Adv 2023; 9 (15) : eade5041 Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis.
Application : IHC-Fr
Reactivity : Mouse
Ohno Y et al. Cancer Sci 2017; 108 (10) : 1959-1966 Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy.
Application : IHC-P
Reactivity : Mouse

Clone Reference

Matson KJE et al. Nat Commun 2022; 13 (1):5628 Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons.
Lin YL et al. Proc Natl Acad Sci U S A 2016; (Epub) in vivo amelioration of endogenous antitumor autoantibodies via low-dose p4n through the lta4h/* a/baff pathway.
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REVIEW

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Application Reference
Morita TY et al. Nat Commun 2023; 14 (1):7490 CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade.
Tong L et al. Sci Adv 2023; 9 (15):eade5041 Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis.
Application : IHC-Fr
Reactivity : Mouse
Ohno Y et al. Cancer Sci 2017; 108 (10):1959-1966 Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy.
Application : IHC-P
Reactivity : Mouse
Clone Reference
Matson KJE et al. Nat Commun 2022; 13 (1):5628 Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons.
Lin YL et al. Proc Natl Acad Sci U S A 2016; (Epub) in vivo amelioration of endogenous antitumor autoantibodies via low-dose p4n through the lta4h/* a/baff pathway.
2015; Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells
Application : IHC-Fr
Ibrahim MK et al. Infect Immun 2014; Deficiency of lymph node resident dendritic cells and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.
Jackson NP et al. Eur J Immunol 2013; 43 (4):897-906 Salmonella polarises peptide-MHC-II presentation towards an unconventional Type B CD4+ T-cell response.
2011; DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity
Application : IHC-P
Reactivity : Mouse
2007; Corticosterone impairs dendritic cell maturation and function
Application : ICC/IF
Reactivity : Mouse
2007; CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity
Application : FACS, Neutralizing/Inhibition
2006; Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration
Application : IHC-Fr
1990; The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies
Application : IP
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339