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CD3 antibody [OKT3] (Low Endotoxin)

Cat. No. GTX79905

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 OKT3

Isotype

 IgG2a

Application

 IHC-Fr, FACS, Functional Assay, in vitro

Reactivity

 Human
Package
100 μg ($399)
See all CD3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
FACS Assay dependent
Functional Assay Assay dependent
in vitro Assay dependent
Not tested in other applications.

Product Note

This antibody recognizes the CD3 antigen of the TCR/CD3 complex on mature human T cells. This antibody, also known as Orthoclone OKT3 or Muromonab-CD3, has been extensively used as a drug for therapy of acute, glucocorticoid resistant rejection of allogenic renal, heart and liver transplants. It has also been investigated for use in treating T-cell acute lymphoblastic leukemia.

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Commercially sensitive information

Purification

Protein A purified

Endotoxin

< 0.01 EU/μg (determined by the LAL assay)

Conjugation

Unconjugated

RRID

AB_11162068

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD3d molecule , CD3e molecule , CD3g molecule , CD3-DELTA , IMD19 , T3D , IMD18 , T3E , TCRE , CD3-GAMMA , IMD17 , T3G

Cellular Localization

Cell membrane; Single-pass type I membrane protein,Cell membrane

Database

Research Area

REFERENCE

Application Reference

R Jing et al. Breast Cancer 2023; IDO-1 impairs antitumor immunity of natural killer cells in triple-negative breast cancer via up-regulation of HLA-G
Application : in vitro
Reactivity : Human
Zheng G et al. Signal Transduct Target Ther 2021; 6 (1) : 236 Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Application : FACS
Submit a Reference

REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399
Custom Conjugations