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CD35 antibody [CR1/4382R]

Anti-CD35 antibody [CR1/4382R] used in IHC (Paraffin sections) (IHC-P). GTX02623
Anti-CD35 antibody [CR1/4382R] used in IHC (Paraffin sections) (IHC-P). GTX02623

Cat. No. GTX02623

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 CR1/4382R

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($529)
See all CD35 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2 μg/ml

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

224 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to human CD35 residues within aa1939-2039

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

complement C3b/C4b receptor 1 (Knops blood group) , C3BR , C4BR , CD35 , KN

Cellular Localization

Membrane

Background

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD35 antibody [CR1/4382R] used in IHC (Paraffin sections) (IHC-P). GTX02623

GTX02623 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX02623 CD35 antibody [CR1/4382R].

Anti-CD35 antibody [CR1/4382R] used in IHC (Paraffin sections) (IHC-P). GTX02623

GTX02623 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX02623 CD35 antibody [CR1/4382R].

REFERENCE

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REVIEW

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Package List Price ($)
$ 529