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CD40 antibody

Anti-CD40 antibody used in Western Blot (WB). GTX13545

Cat. No. GTX13545

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse, Rat, Rabbit, Sheep, Dog, Hamster, Guinea pig, Pig, Monkey
Package
50 μg ($399)
See all CD40 products

APPLICATION

Application Note

Recommended dilutions: WB: 1/1000. Detects a band of approximately 45 kDa (predicted molecular weight: 34 kDa). Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

31 kDa. ( Note )

Positive Control

Rat Testes Tissue Extract

Product Note

The antibody specificity is confirmed by specific peptide inhibition in immunoblotting studies.

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: CQPVTQEDGKESRISVQERQ conjugated to KLH, corresponding to amino acids 258-277 of Human CD40.

Purification

Affinity purified with antigen

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD40 molecule , Bp50 , CDW40 , TNFRSF5 , p50

Background

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

Database

Research Area

DATA IMAGES

Anti-CD40 antibody used in Western Blot (WB). GTX13545

GTX13545 WB Image

"Western blot analysis of CD40: Lane 1: MWM Lane 2: ESK4 cell lysate Lane 3: Molt 4 cell lysate."

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399