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CD44 antibody [IM7] (Biotin)

Anti-CD44 antibody [IM7] (Biotin) used in Flow cytometry (FACS). GTX19629

Cat. No. GTX19629

Reference 4

Host

 Rat

Clonality

 Monoclonal

Clone Name

 IM7

Isotype

 IgG2b

Application

 IHC-Fr, FACS, IP

Reactivity

 Human, Bovine, Cat, Dog, Pig, Horse
Package
125 μg ($399)
See all CD44 products

APPLICATION

Application Note

FACS: Use 1μg for 10^6 cells. IHC-Fr (acetone fixed): Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

82 kDa. ( Note )

Product Note

Recognizes all isoforms of the Pgp-1 cell surface glycoprotein. The CD44 is present on B-cells, monocytes, macrophages and certain subsets of thymocytes and peripheral T-cells. Mice with the Ly-24.1 allotype have high densities of CD44+ T-cells, while Ly-24.2 strains are low expressors.

PROPERTIES

Form

Liquid

Buffer

0.01M PBS pH7.2, 1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

Unfortunately, this information is considered to be commercially sensitive

Purification

Protein A purified

Conjugation

Biotin

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD44 molecule (Indian blood group) , CDW44 , CSPG8 , ECMR-III , HCELL , HUTCH-I , IN , LHR , MC56 , MDU2 , MDU3 , MIC4 , Pgp1

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD44 antibody [IM7] (Biotin) used in Flow cytometry (FACS). GTX19629

GTX19629 FACS Image

Staining of C57 splenocytes with Anti-Mouse CD44: Biotin (purple histogram) or Rat IgG2b Isotype Control: Biotin (open histogram) followed by UltraAvidin: PE

REFERENCE

Clone Reference

de S? Schiavo Matias G et al. Bioengineered 2022; 13 (2):3551-3565 In vivo biocompatibility analysis of the recellularized canine tracheal scaffolds with canine epithelial and endothelial progenitor cells.
Hendawy H et al. Animals (Basel) 2021; 11 (2) Tissue Harvesting Site Effect on the Canine Adipose Stromal Vascular Fraction Quantity and Quality.
Chae HK et al. VETIMM 2017; S0165-2427 (16):30381-6 Immunomodulatory Effects of Soluble Factors Secreted by Feline Adipose Tissue-derived Mesenchymal Stem Cells.
Lin CW et al. Acta Biomater 2016; cd44-specific nanoparticles for redox-triggered reactive oxygen species production and * release.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399