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CD44 antibody [IM7] (FITC)

Anti-CD44 antibody [IM7] (FITC) used in Flow cytometry (FACS). GTX80087

Cat. No. GTX80087

Reference 4

Host

 Rat

Clonality

 Monoclonal

Clone Name

 IM7

Isotype

 IgG3b

Application

 FACS

Reactivity

 Human, Mouse, Cat, Dog, Pig, Baboon, Chimpanzee, Cynomolgus monkey, Horse, Rhesus Monkey
Package
100 μg ($339)
See all CD44 products
PRODUCT

Summary

The IM7 antibody recognizes CD44, a ubiquitously expressed cell surface receptor which is important for extracellular matrix organization, cell-cell and cell-matrix adhesion and migration. CD44 may be expressed in a number of different isoforms (splice variants) from the most typical or “standard” form, known as CD44s, to variants designated CD44v, e.g. CD44v1 or CD44v6. These receptors interact with several ligands, but most often associate with an extracellular matrix component hyaluronate, through which it mediates adhesion.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Not tested in other applications.

Calculated MW

82 kDa. ( Note )

Product Note

This antibody reacts with all isoforms of mouse CD44.

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Fluorescein isothiocyanate (FITC)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD44 molecule (Indian blood group) , CDW44 , CSPG8 , ECMR-III , HCELL , HUTCH-I , IN , LHR , MC56 , MDU2 , MDU3 , MIC4 , Pgp1

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD44 antibody [IM7] (FITC) used in Flow cytometry (FACS). GTX80087

GTX80087 FACS Image

FACS analysis of C57Bl/6 splenocytes using GTX80087 CD44 antibody [IM7] (FITC).
Solid line : Primary antibody
Dashed line : FITC rat IgG2b isotype control
Antibody amount : 0.5 μg

REFERENCE

Clone Reference

de S? Schiavo Matias G et al. Bioengineered 2022; 13 (2):3551-3565 In vivo biocompatibility analysis of the recellularized canine tracheal scaffolds with canine epithelial and endothelial progenitor cells.
Hendawy H et al. Animals (Basel) 2021; 11 (2) Tissue Harvesting Site Effect on the Canine Adipose Stromal Vascular Fraction Quantity and Quality.
Chae HK et al. VETIMM 2017; S0165-2427 (16):30381-6 Immunomodulatory Effects of Soluble Factors Secreted by Feline Adipose Tissue-derived Mesenchymal Stem Cells.
Lin CW et al. Acta Biomater 2016; cd44-specific nanoparticles for redox-triggered reactive oxygen species production and * release.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339