GeneTex

  • Country / Location Selection

United States (US)

CD45 antibody

Cat. No. GTX82139

Host

 Chicken

Clonality

 Polyclonal

Isotype

 IgY

Application

 WB

Reactivity

 Human
Package
50 μg ($519)
See all CD45 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
Not tested in other applications.

Calculated MW

147 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Immunogen Sequence: GI # 18641347, sequence 482-552 Recombinant protein tyrosine phosphatase, receptor type, C isoform 1

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

protein tyrosine phosphatase receptor type C , B220 , CD45 , CD45R , GP180 , L-CA , LCA , LY5 , T200

Cellular Localization

Cell membrane

Background

Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity. while the second one seems to affect the substrate specificity of the first one. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth. differentiation. mitotic cycle. and oncogenic transformation. This PTP contains an extracellular domain. a single transmembrane segment and two tandem intracytoplasmic catalytic domains. and thus belongs to receptor type PTP. This protein is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes. or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases. and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene. which encode distinct isoforms. have been reported.

Database

Research Area

REFERENCE

There are currently no references for CD45 antibody (GTX82139). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for CD45 antibody (GTX82139). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 519