GeneTex

  • Country / Location Selection

United States (US)

CD59 antibody [MEM-129] (Azide Free)

Cat. No. GTX14221

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MEM-129

Isotype

 IgM

Application

 FACS, Functional Assay

Reactivity

 Human, Pig
Package
100 μg ($399)
See all CD59 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Functional Assay Assay dependent
Not tested in other applications.

Calculated MW

14 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.2μm filter-sterilized HEPES buffered saline solution

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human peripheral blood lymphocytes

Purification

Purified by precipitation and chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD59 , CD59 molecule , EJ16 , EJ30 , EL32 , G344 , HRF20 , MACIF , MACIP , MEM43 , MIC11 , MIN1 , MIN2 , MIN3 , MIRL , MSK21 , p1820 , CD59 molecule (CD59 blood group) , 1F5 , 16.3A5

Cellular Localization

Cell membrane,Secreted

Background

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

There are currently no references for CD59 antibody [MEM-129] (Azide Free) (GTX14221). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for CD59 antibody [MEM-129] (Azide Free) (GTX14221). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 399