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CD8 alpha antibody [CD8/4391R]

Anti-CD8 alpha antibody [CD8/4391R] used in IHC (Paraffin sections) (IHC-P). GTX02616
Anti-CD8 alpha antibody [CD8/4391R] used in IHC (Paraffin sections) (IHC-P). GTX02616
Anti-CD8 alpha antibody [CD8/4391R] used in Protein Array (Protein Array). GTX02616
Anti-CD8 alpha antibody [CD8/4391R] used in IHC (Paraffin sections) (IHC-P). GTX02616
Anti-CD8 alpha antibody [CD8/4391R] used in IHC (Paraffin sections) (IHC-P). GTX02616

Cat. No. GTX02616

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 CD8/4391R

Isotype

 IgG

Application

 IHC-P, Protein Array

Reactivity

 Human
Package
100 μg ($529)
See all CD8 alpha products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2 μg/ml
Protein Array Assay dependent

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

26 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to human CD8α residues within aa135-235

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD8a molecule , CD8 , Leu2 , p32

Background

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Database

Research Area

DATA IMAGES

Anti-CD8 alpha antibody [CD8/4391R] used in IHC (Paraffin sections) (IHC-P). GTX02616

GTX02616 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX02616 CD8 alpha antibody [CD8/4391R].

Anti-CD8 alpha antibody [CD8/4391R] used in IHC (Paraffin sections) (IHC-P). GTX02616

GTX02616 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX02616 CD8 alpha antibody [CD8/4391R].

Anti-CD8 alpha antibody [CD8/4391R] used in Protein Array (Protein Array). GTX02616

GTX02616 Protein Array Image

Analysis of Protein Array containing more than 19,000 full-length human proteins using CD8a Recombinant Rabbit Monoclonal Antibody (CD8/4391R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Anti-CD8 alpha antibody [CD8/4391R] used in IHC (Paraffin sections) (IHC-P). GTX02616

GTX02616 IHC-P Image

IHC-P analysis of human lymph node tissue section using GTX02616 CD8 alpha antibody [CD8/4391R].

Anti-CD8 alpha antibody [CD8/4391R] used in IHC (Paraffin sections) (IHC-P). GTX02616

GTX02616 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX02616 CD8 alpha antibody [CD8/4391R].

REFERENCE

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REVIEW

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Package List Price ($)
$ 529