APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500-1:5000 |
| 1:500 |
| 1:100 |
| 1:5000-1:20000 |
Not tested in other applications.
Calculated MW
Product Note
No reaction was observed against other related cyclin dependent kinases. Cross reactivity with cdk5 (p31) from other species may also occur.
PROPERTIES
Form
Liquid
Buffer
Filtered-steriled serum
Preservative
0.01% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
85 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
cdk5 (p31) peptide corresponding to the C-terminus of the human protein conjugated to KLH.
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
cyclin dependent kinase 5 , LIS7 , PSSALRE
Cellular Localization
Cytoplasm,Cell membrane,Perikaryon,Cell projection,Lamellipodium,Growth cone,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Nucleus
Background
The protein encoded by the gene CDK5 is involved in the control of the cell cycle and interacts with D1 and D3-type G1 cyclins. CDK5 belongs to the protein kinase superfamily, the CMGC Ser/Thr protein kinase family and the CDC2/CDKX subfamily. CDK5 phosphorylates histone H1, tau, MAP2 and NF-H and NF-M and also interacts with p35 which activates the kinase. CDK5 forms a heterodimer, where CDK5 is the catalytic subunit and p35 is the regulatory subunit. CDK5 is also found in a trimolecular complex with CABLES1 and ABL1. CDK5 is a cytoplasmic protein.
Database
Research Area
DATA IMAGES
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GTX26543 IHC-P Image
GeneTex anti-CDK5 antibody (GTX26543) was diluted 1:500 to detect CDK5 in human brain cortex tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain.
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GTX26543 IHC-P Image
IHC-P analysis of Human brain cortex tissue using GTX26543 CDK5 antibody.
Dilution : 1:500
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REFERENCE
There are currently no references for CDK5 antibody (GTX26543). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CDK5 antibody (GTX26543). Be the first to share your experience with this product.
