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CUEDC1 antibody

Anti-CUEDC1 antibody used in Western Blot (WB). GTX85378
Anti-CUEDC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85378
Anti-CUEDC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85378

Cat. No. GTX85378

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all CUEDC1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 1 μg/mL
IHC-P 2 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

42 kDa. ( Note )

Positive Control

Rat Liver Tissue Lysate(GTX27943) , Human Liver Tissue Slide

Product Note

CUEDC1 antibody will not cross-react with CUEDC2.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

CUEDC1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human CUEDC1.The immunogen is located within amino acids 310 - 360 of CUEDC1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CUE domain containing 1

Background

The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC1 (CUE domain-containing protein 1) is a 386 amino acid protein that contains one CUE domain, suggesting a possible role in protein trafficking and degradation pathways. Two isoforms of CUEDC1 exist due to alternative splicing events. Defects in the gene encoding CUEDC1 may be associated with early stage cervical cancer, implicating CUEDC1 as a potential tumor marker. CUEDC1 antibody will not cross-react with CUEDC2.

Database

Research Area

DATA IMAGES

Anti-CUEDC1 antibody used in Western Blot (WB). GTX85378

GTX85378 WB Image

WB analysis of rat liver tissue lysate using GTX85378 CUEDC1 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml

Anti-CUEDC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85378

GTX85378 IHC-P Image

IHC-P analysis of human liver tissue using GTX85378 CUEDC1 antibody.
Working concentration : 2 μg/ml

Anti-CUEDC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85378

GTX85378 IHC-P Image

IHC-P analysis of human liver tissue using GTX85378 CUEDC1 antibody.
Working concentration : 20 μg/ml

REFERENCE

Application Reference

Cui Y et al. Aging (Albany NY) 2020; 12 (20) : 20047-20068 CUEDC1 inhibits epithelial-mesenchymal transition via the TβRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer.
Application : IHC-P
Reactivity : Human
Submit a Reference

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399