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CXCR4 antibody

Anti-CXCR4 antibody used in IHC (Paraffin sections) (IHC-P). GTX21671

Cat. No. GTX21671

Reference 1

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Rat
Package
100 μg ($399)
See all CXCR4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:250
IHC-P 1:300
ELISA 1:25,000
Not tested in other applications.

Calculated MW

40 kDa. ( Note )

Product Note

Peptide sequence is < 50 % identical to other human chemokine receptors in this region.

PROPERTIES

Form

Liquid

Buffer

10mM KHPO₄, 140mM NaCl, 0.1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide TEEMGSGDYDSMKEPCFREENANFNKC corresponding to N-terminal extracellular domain of human CXCR4 receptor

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD184,CXC motif chemokine receptor 4,CXCR4,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM,WHIMS,C-X-C motif chemokine receptor 4

Cellular Localization

Cell membrane,Cell junction,Early endosome,Late endosome,Lysosome

Background

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CXCR4 antibody used in IHC (Paraffin sections) (IHC-P). GTX21671

GTX21671 IHC-P Image

IHC-P analysis of human spleen tissue using GTX21671 CXCR4 antibody.

REFERENCE

Application Reference

Chen J et al. Nat Commun 2023; 14 (1) : 5894 CREB1-driven CXCR4(hi) neutrophils promote skin inflammation in mouse models and human patients.
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REVIEW

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Package List Price ($)
$ 399