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Caldesmon antibody [CALD1/1424R]

Anti-Caldesmon antibody [CALD1/1424R] used in IHC (Paraffin sections) (IHC-P). GTX02598
Anti-Caldesmon antibody [CALD1/1424R] used in IHC (Paraffin sections) (IHC-P). GTX02598

Cat. No. GTX02598

Reference 1

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 CALD1/1424R

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human, Rat
Package
100 μg ($529)
See all Caldesmon products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2 μg/ml

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA (pH 7.5-8.5) for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

93 kDa. ( Note )

Product Note

This antibody recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human full-length CALD1 protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

caldesmon 1 , CDM , H-CAD , HCAD , L-CAD , LCAD , NAG22

Cellular Localization

Cytoplasm, cytoskeleton

Background

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Caldesmon antibody [CALD1/1424R] used in IHC (Paraffin sections) (IHC-P). GTX02598

GTX02598 IHC-P Image

IHC-P analysis of human uterus tissue section using GTX02598 Caldesmon antibody [CALD1/1424R].

Anti-Caldesmon antibody [CALD1/1424R] used in IHC (Paraffin sections) (IHC-P). GTX02598

GTX02598 IHC-P Image

IHC-P analysis of rat uterus tissue section using GTX02598 Caldesmon antibody [CALD1/1424R].

REFERENCE

Application Reference

Umur LF et al. Cureus 2021; 13 (2) : e13073 Intravenous Leiomyosarcoma of the Lower Extremity: As Peripheral as It Gets.
Reactivity : Human
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REVIEW

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Package List Price ($)
$ 529