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Calpain 6 antibody

Anti-Calpain 6 antibody used in IHC (Paraffin sections) (IHC-P). GTX85383
Anti-Calpain 6 antibody used in IHC (Paraffin sections) (IHC-P). GTX85383
Anti-Calpain 6 antibody used in Western Blot (WB). GTX85383

Cat. No. GTX85383

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all Calpain 6 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 1 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

75 kDa. ( Note )

Positive Control

Rat Lung Tissue Lysate(GTX27941) , Human Lung Tissue Slide

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

CAPN6 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human CAPN6.The immunogen is located within the last 50 amino acids of CAPN6.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

calpain 6 , CANPX , CAPNX , CalpM , DJ914P14.1

Background

Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.

Database

Research Area

DATA IMAGES

Anti-Calpain 6 antibody used in IHC (Paraffin sections) (IHC-P). GTX85383

GTX85383 IHC-P Image

IHC-P analysis of human lung tissue using GTX85383 Calpain 6 antibody.
Working concentration : 2.5 μg/ml

Anti-Calpain 6 antibody used in IHC (Paraffin sections) (IHC-P). GTX85383

GTX85383 IHC-P Image

IHC-P analysis of human lung tissue using GTX85383 Calpain 6 antibody.
Working concentration : 20 μg/ml

Anti-Calpain 6 antibody used in Western Blot (WB). GTX85383

GTX85383 WB Image

WB analysis of rat lung tissue lysate using GTX85383 Calpain 6 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399