GeneTex

  • Country / Location Selection

United States (US)

Chemokine Receptor D6 antibody

Anti-Chemokine Receptor D6 antibody used in IHC (Paraffin sections) (IHC-P). GTX21658

Cat. No. GTX21658

Reference 1

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, FACS, ELISA, Neutralizing/Inhibition

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all Chemokine Receptor D6 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
IHC-P 1:125
FACS 2-6μl/10⁶cells/50-100μl
ELISA 1:50,000
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

43 kDa. ( Note )

Product Note

Peptide sequence is < 50 % identical to other chemokine receptors in this region.

PROPERTIES

Form

Liquid

Buffer

10mM KHPO₄, 140mM NaCl, 0.1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide C-LATEDADSENSSFYYYDYLDEVAFML corresponding to the N-terminal extracellular domain of human D6

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ACKR2,CCBP2,CCR10,CCR9,CMKBR9,D6,atypical chemokine receptor 2,hD6,Chemokine Receptor D6

Cellular Localization

Early endosome,Recycling endosome,Cell membrane

Background

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Chemokine Receptor D6 antibody used in IHC (Paraffin sections) (IHC-P). GTX21658

GTX21658 IHC-P Image

IHC-P analysis of human spleen tissue using GTX21658 Chemokine Receptor D6 antibody.

REFERENCE

Application Reference

Chang TM et al. Int J Biol Sci 2023; 19 (5) : 1455-1470 CXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway.
Application : WB, IHC-P, Neutralizing/Inhibition
Reactivity : Human
Submit a Reference

REVIEW

There are currently no reviews for Chemokine Receptor D6 antibody (GTX21658). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 399