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Cyclin D1 antibody

Orthogonal
Anti-Cyclin D1 antibody used in Western Blot (WB). GTX27958
Anti-Cyclin D1 antibody used in Western Blot (WB). GTX27958
Anti-Cyclin D1 antibody used in Western Blot (WB). GTX27958

Cat. No. GTX27958

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC

Reactivity

 Human, Mouse, Rat
Package
1 ml ($399)
See all Cyclin D1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:200
IHC Assay dependent
Not tested in other applications.

Calculated MW

34 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX28013).

PROPERTIES

Form

Liquid

Buffer

PBS, 0.2% Gelatin

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide mapping to the carboxy terminus of human cyclin D1.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_386014

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cyclin D1 , BCL1 , D11S287E , PRAD1 , U21B31

Cellular Localization

Nucleus , Cytoplasm , Membrane

Background

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Cyclin D1 antibody used in Western Blot (WB). GTX27958

GTX27958 WB Image

Orthogonal

The data was published in the journal Int J Mol Sci in 2018. PMID: 29522490

Anti-Cyclin D1 antibody used in Western Blot (WB). GTX27958

GTX27958 WB Image

Orthogonal

The data was published in the journal Int J Mol Sci in 2018. PMID: 29522490

Anti-Cyclin D1 antibody used in Western Blot (WB). GTX27958

GTX27958 WB Image

Orthogonal

The data was published in the journal Int J Mol Sci in 2018. PMID: 29522490

REFERENCE

Application Reference

Wu CH et al. Int J Mol Sci 2018; 19 (3) Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model.
Application : WB
Reactivity : Human
Liu FC et al. Phytomedicine 2013; 20 (10) : 874-82 Elucidating the inhibitory mechanisms of the ethanolic extract of the fruiting body of the mushroom Antrodia cinnamomea on the proliferation and migration of murine leukemia WEHI-3 cells and their tumorigenicity in a BALB/c allograft tumor model.
Application : WB
Reactivity : Mouse
Submit a Reference

REVIEW

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Package List Price ($)
$ 399