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DAP12 antibody

Anti-DAP12 antibody used in Immunoprecipitation (IP). GTX16462

Cat. No. GTX16462

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IP

Reactivity

 Human, Mouse
Package
100 μg ($489)
See all DAP12 products

APPLICATION

Application Note

IP: Use at a concentration of 2-4 μg/mg of protein lysate. WB: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

12 kDa. ( Note )

Positive Control

NKp44 positive cells.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full length protein (Human).

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TYRO protein tyrosine kinase binding protein , DAP12 , KARAP , PLOSL , PLOSL1

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Database

Research Area

DATA IMAGES

Anti-DAP12 antibody used in Immunoprecipitation (IP). GTX16462

GTX16462 IP Image

GTX16462 at 3g (per mg of protein lysate)detecting DAP12 on MHC ClassI postive cells (Lane 1) and NKp44 postive cells (Lane 2) by immunoprecipitation.

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 489