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DKC1 antibody

Anti-DKC1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX87872
Anti-DKC1 antibody used in Western Blot (WB). GTX87872

Cat. No. GTX87872

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF

Reactivity

 Human
Package
100 μg ($399)
See all DKC1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500~1:1000
ICC/IF 1:100~1:500
Not tested in other applications.

Calculated MW

58 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human DKC1 (171-220).

Purification

Purified by antigen-affinity chromatography
From serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CBF5 , DKC , DKC1 , DKCX , NAP57 , NOLA4 , XAP101 , dyskerin pseudouridine synthase 1 , dyskeratosis congenita 1, dyskerin

Cellular Localization

Nucleus,Nucleolus,Nucleus,Cajal body,Cytoplasm

Background

This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Database

Research Area

DATA IMAGES

Anti-DKC1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX87872

GTX87872 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX87872 DKC1 antibody. The picture on the right is blocked with the synthesized peptide.

Anti-DKC1 antibody used in Western Blot (WB). GTX87872

GTX87872 WB Image

WB analysis of Jurkat cell lysates using GTX87872 DKC1 antibody. The lane on the right is blocked with the synthesized peptide.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399