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DNAL1 antibody

Anti-DNAL1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85387
Anti-DNAL1 antibody used in Western Blot (WB). GTX85387
Anti-DNAL1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85387

Cat. No. GTX85387

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all DNAL1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
ICC/IF 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

22 kDa. ( Note )

Positive Control

3T3 (NIH) Cell Lysate(GTX27179) , 3T3/BALB Cell Slide

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

DNAL1 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human DNAL1.The immunogen is located within the last 50 amino acids of DNAL1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

dynein axonemal light chain 1 , C14orf168 , CILD16 , LC1

Background

DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.

Database

Research Area

DATA IMAGES

Anti-DNAL1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85387

GTX85387 ICC/IF Image

ICC/IF analysis of 3T3 cells using GTX85387 DNAL1 antibody.
Green : Primary antibody
Blue : DAPI
Dilution : 20 μg/ml

Anti-DNAL1 antibody used in Western Blot (WB). GTX85387

GTX85387 WB Image

WB analysis of 3T3 cell lysate using GTX85387 DNAL1 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-DNAL1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85387

GTX85387 ICC/IF Image

ICC/IF analysis of 3T3 cells using GTX85387 DNAL1 antibody.
Working concentration : 2.5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399