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DR1 antibody

Anti-DR1 antibody used in Western Blot (WB). GTX55597
Anti-DR1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55597
Anti-DR1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55597
Anti-DR1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55597

Cat. No. GTX55597

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all DR1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:200
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

19 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_001929.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

down-regulator of transcription 1 , NC2 , NC2-BETA , NC2B , NCB2

Cellular Localization

Nucleus

Background

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-DR1 antibody used in Western Blot (WB). GTX55597

GTX55597 WB Image

WB analysis of various sample lysates using GTX55597 DR1 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-DR1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55597

GTX55597 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX55597 DR1 antibody.
Dilution : 1:100

Anti-DR1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55597

GTX55597 IHC-P Image

IHC-P analysis of rat kidney tissue using GTX55597 DR1 antibody.
Dilution : 1:100

Anti-DR1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55597

GTX55597 ICC/IF Image

ICC/IF analysis of MCF7 cells using GTX55597 DR1 antibody.

REFERENCE

Application Reference

Li H et al. Int J Mol Med 2022; 49 (1) The DR1?CSE/H2S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.
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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399