APPLICATION
Application Note
IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Optimal dilutions/concentrations should be determined by the end user.
Calculated MW
Positive Control
Skeletal muscle
PROPERTIES
Form
Liquid
Buffer
PBS, 1% BSA
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Antigen Species
Human
Immunogen
Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (C terminal).
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
dysferlin , FER1L1 , LGMD2B , LGMDR2 , MMD1
Cellular Localization
Cell membrane
Background
The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2008]
Database
Research Area
DATA IMAGES
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GTX15109 IHC-P Image
Human Skeletal Muscle stained with anti-Dysferlin antibody (GTX15108)
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GTX15109 IHC Image
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GTX15109 IHC-P Image
GTX15109 staining Dysferlin in human skeletal muscle by Immunohistochemistry (FFPE-sections).
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REFERENCE
There are currently no references for Dysferlin antibody (Ready-to-use) (GTX15109). Be the first to share your publications with this product.
REVIEW
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