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EGFR antibody [ICR10] (PE)

Cat. No. GTX75350

Reference 7

Host

 Rat

Clonality

 Monoclonal

Clone Name

 ICR10

Isotype

 IgG2a

Application

 FACS

Reactivity

 Human
Package
50 test ($289)
See all EGFR products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Neat

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.
Not tested in other applications.

Calculated MW

134 kDa. ( Note )

Product Note

This antibody, clone ICR10 binds to epitope B from EGFR

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 5% Sucrose

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Extracellular domain of human EGF-receptor from head and neck carcinoma.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Phycoerythrin (PE)

RRID

AB_376734

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

epidermal growth factor receptor , ERBB , ERBB1 , HER1 , NISBD2 , PIG61 , mENA

Cellular Localization

Cell membrane , Endoplasmic reticulum membrane , Endosome , Endosome membrane , Nucleus

Background

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]

Database

Research Area

REFERENCE

Clone Reference

Schwab FD et al. Microsyst Nanoeng 2022; 8:130 MyCTC chip: microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies.
Manuel C Scheidmann et al. Cancer Res 2022; 82 (4):681-694 An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression.
Donato C et al. Cell Rep 2020; 32 (10):108105 Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells.
Gkountela S et al. Cell 2019; 176 (2023/1/2):98-112.e14 Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding.
Szczerba BM et al. Nature 2019; (Epub) Neutrophils escort circulating tumour cells to enable cell cycle progression.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 289