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ERAB antibody [10D12]

Cat. No. GTX10259

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 10D12

Isotype

 IgG2b

Application

 WB, IHC-Fr, Dot

Reactivity

 Human
Package
100 μl ($429)
See all ERAB products

APPLICATION

Application Note

Dot: Use at a dilution of 1/100 - 1/1000. IHC: Use at a dilution of 1/100 - 1/1000. WB: Use at a dilution of 1/100 - 1/1000. Predicted molecular weight: 27 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

27 kDa. ( Note )

Product Note

This antibody recognizes the recombinant human ERAB protein (27kDa) and the endogenous ERAB protein in cell extracts in immunoblots and ELISA assays, with virtually no crossreactivity with other human proteins.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant, full-length Human ERAB protein (Fusion protein).

Purification


Ammonium sulfate precipitated and dialyzed tissue culture supernatant.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

hydroxysteroid 17-beta dehydrogenase 10 , 17b-HSD10 , ABAD , CAMR , DUPXp11.22 , ERAB , HADH2 , HCD2 , HSD10MD , MHBD , MRPP2 , MRX17 , MRX31 , MRXS10 , SCHAD , SDR5C1

Cellular Localization

Mitochondrion

Background

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 429