GeneTex

  • Country / Location Selection

United States (US)

Endostatin antibody [1837-46]

Cat. No. GTX54468

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 1837-46

Isotype

 IgG2b

Application

 WB, IHC-P, IHC-Fr, FACS, ELISA

Reactivity

 Human
Package
50 μg ($399)
See all Endostatin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

178 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

100 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Purified IgG2b

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

COL18A1,KNO,KNO1,KS,collagen type XVIII alpha 1 chain,Collagen XVIII

Cellular Localization

Secreted,Extracellular space,Extracellular matrix,Basement membrane

Background

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Database

Research Area

REFERENCE

There are currently no references for Endostatin antibody [1837-46] (GTX54468). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for Endostatin antibody [1837-46] (GTX54468). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 399