GeneTex

  • Country / Location Selection

United States (US)

FBXL16 antibody

Anti-FBXL16 antibody used in Western Blot (WB). GTX31424
Anti-FBXL16 antibody used in IHC (Paraffin sections) (IHC-P). GTX31424
Anti-FBXL16 antibody used in IHC (Paraffin sections) (IHC-P). GTX31424

Cat. No. GTX31424

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all FBXL16 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 1 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

52 kDa. ( Note )

Positive Control

Human Spleen Tissue Lysate(GTX27921) , Human Spleen Tissue Slide

Product Note

FBXL16 antibody is predicted to not cross-react with other F-box protein family members.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

FBXL16 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human FBXL16.The immunogen is located within the last 50 amino acids of FBXL16.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

F-box and leucine rich repeat protein 16 , C16orf22 , Fbl16 , c380A1.1

Background

Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Database

Research Area

DATA IMAGES

Anti-FBXL16 antibody used in Western Blot (WB). GTX31424

GTX31424 WB Image

WB analysis of human spleen tissue lysate using GTX31424 FBXL16 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml

Anti-FBXL16 antibody used in IHC (Paraffin sections) (IHC-P). GTX31424

GTX31424 IHC-P Image

IHC-P analysis of human spleen tissue using GTX31424 FBXL16 antibody.
Working concentration : 20 μg/ml

Anti-FBXL16 antibody used in IHC (Paraffin sections) (IHC-P). GTX31424

GTX31424 IHC-P Image

IHC-P analysis of human spleen tissue using GTX31424 FBXL16 antibody.
Working concentration : 5 μg/ml

REFERENCE

Application Reference

Morel M et al. Mol Oncol 2024; 18 (3) : 762-777 FBXL16 promotes cell growth and drug resistance in lung adenocarcinomas with KRAS mutation by stabilizing IRS1 and upregulating IRS1/AKT signaling.
Morel M et al. J Biol Chem 2020; 295 (23) : 7970-7980 The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

There are currently no reviews for FBXL16 antibody (GTX31424). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399