APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| 5 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Mouse, Rat, Bovine, Guinea pig, Horse(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human FZD4. Synthetic peptide located within the following region: GITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
frizzled class receptor 4 , CD344 , EVR1 , FEVR , FZD4S , Fz-4 , Fz4 , FzE4 , GPCR , hFz4
Cellular Localization
Membrane; Multi-pass membrane protein , Cell membrane
Background
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX01572 WB Image
WB analysis of human fetal liver tissue lysate using GTX01572 Frizzled 4 antibody.
Dilution : 1.0μg/ml
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GTX01572 IHC-P Image
IHC-P analysis of human skin tissue using GTX01572 Frizzled 4 antibody.
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GTX01572 WB Image
WB analysis of various sample lysates using GTX01572 Frizzled 4 antibody.
Positive control (+) : Human lung (LU)
Negative control (-) : 293T (2T)
Dilution : 1.0μg/ml
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GTX01572 WB Image
WB analysis of human lung tumor tissue lysate using GTX01572 Frizzled 4 antibody.
Dilution : 1.0μg/ml
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GTX01572 WB Image
WB analysis of RPMI 8226 cell lysate using GTX01572 Frizzled 4 antibody.
Dilution : 1.0μg/ml
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REFERENCE
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REVIEW
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