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GP IIb/IIIa antibody [237]

Cat. No. GTX20662

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 237

Isotype

 IgG1

Application

 WB

Reactivity

 Human
Package
100 μg ($399)
See all GP IIb/IIIa products

APPLICATION

Application Note

This antibody, used at a concentration of 10-20μg/mL will allow visualization of NP 40 solubized normal human platelets

Product Note

Under reducing conditions, this antibody will bind against the human platelet membrane glycoproteins IIb and/or IIIa, which have molecular weights of ~130,000 (IIb) and 115,000 (IIIa).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

109 human platelets suspension. The supernatant fluid from positive clones was screened by ELISA coated with washed platelets

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD61 , GP3A , HPA3 , Integrin beta3 antibody , Integrin beta 3 antibody , Integrin alpha2b , Integrin alpha 2b , GPIIIa , CD41b , GP IIb/IIIa , GPIIIb , GTA , CD41 , GP2B , GPIIb

Background

The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated alpha and beta subunits. CD61 non-covalently associates with CD41 (alpha Ilb integrin) and is expressed by megakaryocytes and platelets. The CD61/CD41 complex acts as a receptor for such adhesive ligands as fibronectin, fibrinogen and von Willebrand factor during platelet stimulation.

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399
Custom Conjugations