APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:300-1:5000 |
| 1:200-1:400 |
Not tested in other applications.
Calculated MW
Predict Reactivity
Rabbit, Sheep, Bovine, Dog, Pig, Horse(>80% identity)
PROPERTIES
Form
Liquid
Buffer
0.01M TBS, 1% BSA, 50% Glycerol
Preservative
0.03% Proclin300
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
KLH conjugated synthetic peptide derived from human GnRHR (201-328).
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
gonadotropin releasing hormone receptor , GNRHR1 , GRHR , HH7 , LHRHR , LRHR
Cellular Localization
Cell membrane; Multi-pass membrane protein
Background
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX03928 WB Image
WB analysis of U251 cell lysates using GTX03928 GnRHR antibody.
Dilution : 1:300
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GTX03928 IHC-P Image
IHC-P analysis of rat brain tissue using GTX03928 GnRHR antibody.
Dilution : 1:200
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GTX03928 WB Image
WB analysis of various lysates using GTX03928 GnRHR antibody.
Lane 1 : Mouse cerebrum
Lane 2 : A549 cells
Dilution : 1:1000
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GTX03928 IHC-P Image
IHC-P analysis of rat brain tissue using GTX03928 GnRHR antibody.
Dilution : 1:200
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REFERENCE
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REVIEW
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