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HCN4 antibody

Anti-HCN4 antibody used in IHC (Frozen sections) (IHC-Fr). GTX54825
Anti-HCN4 antibody used in Western Blot (WB). GTX54825

Cat. No. GTX54825

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-Fr, IP

Reactivity

 Human, Mouse, Rat
Package
50 μl ($639)
See all HCN4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

129 kDa. ( Note )

Predict Reactivity

Rabbit(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

GST fusion protein with sequence HGHLHDSAEERRLIAEGDASPG EDRTPPGLAAEPERP, corresponding to amino acid residues 119-155 (Intracellular, N-terminus) of human HCN4 (Accession  : Q9Y3Q4), (MW: 31 kDa.).

Purification

Depleted of anti-GST antibodies by affinity chromatography on immobilized GST and purified by antigen-affinity chromatography.
From serum

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

hyperpolarization activated cyclic nucleotide gated potassium channel 4 , SSS2

Cellular Localization

Cell membrane

Background

This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]

Database

Research Area

DATA IMAGES

Anti-HCN4 antibody used in IHC (Frozen sections) (IHC-Fr). GTX54825

GTX54825 IHC-Fr Image

IHC-Fr analysis of mouse thalamus tissue using GTX54825 HCN4 antibody.
Panel A : HCN4 (red) appears in the neuropil of the lateral nucleus (LN).
Panel B : Staining of reticular nucleus (RN) with mouse anti-Parvalbumin.
Panel C : Merge of HCN4 and Parvalbumin images demonstrates separate localization of these proteins in the thalamus.

Anti-HCN4 antibody used in Western Blot (WB). GTX54825

GTX54825 WB Image

WB analysis of rat brain membrane lysate using GTX54825 HCN4 antibody preincubated with or without immunogen peptide.
Dilution : 1:200

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 639