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HLA-E antibody [MEM-E/06]

Anti-HLA-E antibody [MEM-E/06] used in IHC (Paraffin sections) (IHC-P). GTX23984

Cat. No. GTX23984

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MEM-E/06

Isotype

 IgG1

Application

 IHC-P, FACS, IP

Reactivity

 Human, Primate
Package
100 μg ($399)
See all HLA-E products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent
FACS Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

40 kDa. ( Note )

Product Note

This antibody reacts with some classical MHC Class I molecules (HLA-A3, -A11, -B7). However, the recent Workshop I Session on the 3rd International Conference on HLA-G (Paris, July 2003) confirmed that the antibody exhibits much broader cross-reactivity classical MHC Class I antigens, namely with HLA-A24, -A32, -B8, -B15, -B27, -B35, -B44, -B54, -C3, -C4, -C5, -C7.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Bacterially expressed recombinant HLA-E refolded with beta2-microglobulin and peptide.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

HLA6.2 , HLAE , QA1 , major histocompatibility complex, class I, E , HLA-E

Cellular Localization

Membrane

Background

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-HLA-E antibody [MEM-E/06] used in IHC (Paraffin sections) (IHC-P). GTX23984

GTX23984 IHC-P Image

IHC-P analysis of human spleen tissue using GTX23984 HLA-E antibody [MEM-E/06].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399