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ICAM2 antibody [CBRIC2/2] (Low endotoxin, azide free)

Cat. No. GTX42520

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 CBRIC2/2

Isotype

 IgG2a

Application

 IHC-Fr, FACS, IP, Functional Assay

Reactivity

 Human
Package
100 μg ($399)
See all ICAM2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
FACS 1/100
IP Assay dependent
Functional Assay Assay dependent

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.
Not tested in other applications.

Calculated MW

31 kDa. ( Note )

Product Note

This antibody recognizes human ICAM2. Clone CBRIC2/2 is reported to inhibit interactions between ICAM2 and LFA-1 (De Fougerolles et al. 1991).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Transfected COS cells expressing ICAM-2 cDNA.

Purification

Protein G purified
From tissue culture supernatant

Endotoxin

< 0.01 EU/μg (determined by the LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

intercellular adhesion molecule 2 , CD102

Cellular Localization

Membrane

Background

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Clone Reference

Monel B et al. Cell Rep 2019; 27 (1):142-153.e4 HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells.
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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399
Custom Conjugations