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IDO1 antibody [10.1]

KO/KD Orthogonal
Anti-IDO1 antibody [10.1] used in Western Blot (WB). GTX54075
Anti-IDO1 antibody [10.1] used in Western Blot (WB). GTX54075
Anti-IDO1 antibody [10.1] used in Western Blot (WB). GTX54075

Cat. No. GTX54075

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 10.1

Isotype

 IgG3

Application

 WB, IHC-Fr

Reactivity

 Human, Mouse
Package
50 μg ($529)
See all IDO1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

45 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide corresponding to amino acids 78-184 of human IDO fused to GST.

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

indoleamine 2,3-dioxygenase 1 , IDO , IDO-1 , INDO

Cellular Localization

Cytoplasm, cytosol

Background

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES

Anti-IDO1 antibody [10.1] used in Western Blot (WB). GTX54075

GTX54075 WB Image

KO/KD Orthogonal

The data was published in the journal Front Immunol in 2019. PMID: 31681271

Anti-IDO1 antibody [10.1] used in Western Blot (WB). GTX54075

GTX54075 WB Image

Orthogonal

The data was published in the journal Front Immunol in 2019. PMID: 31681271

Anti-IDO1 antibody [10.1] used in Western Blot (WB). GTX54075

GTX54075 WB Image

Orthogonal

The data was published in the journal Front Immunol in 2019. PMID: 31681271

REFERENCE

Application Reference

Zhang J et al. Front Immunol 2019; 10 : 2358 Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529