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IGF1R beta (phospho Tyr1131) / Insulin Receptor beta (phospho Tyr1146) antibody

Anti-IGF1R beta (phospho Tyr1131) / Insulin Receptor beta (phospho Tyr1146) antibody used in Western Blot (WB). GTX52315

Cat. No. GTX52315

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IP, IHC

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all IGF1R products

APPLICATION

Application Note

WB 1:500-1:2000, IHC 1:50-1:200, IP

Calculated MW

155 kDa. ( Note )

Product Note

Tyr1161 in full-length IGF-1R is equivalent toTyr1131 in signal peptide cleaved IGF1R, and Tyr1185 in full-length Insulin Receptor is equivalent to Tyr1146 in signal peptide cleaved Insulin Receptor.

PROPERTIES

Form

Liquid

Buffer

PBS, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthesized peptide derived from human IGF1R around the phosphorylation site of Tyr1161, which is equivalent to Tyrosine 1131 in signal peptide cleaved IGF1R.

Purification

Antigen affinity purification

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

insulin like growth factor 1 receptor , CD221 , IGFIR , IGFR , JTK13

Cellular Localization

Cell membrane

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Research Area

DATA IMAGES

Anti-IGF1R beta (phospho Tyr1131) / Insulin Receptor beta (phospho Tyr1146) antibody used in Western Blot (WB). GTX52315

GTX52315 WB Image

Western blot analysis of IGF1R phosphorylation expression in Insulin treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399