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IZUMO1 antibody

Anti-IZUMO1 antibody used in Western Blot (WB). GTX00746
Anti-IZUMO1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00746
Anti-IZUMO1 antibody used in IHC (Paraffin sections) (IHC-P). GTX00746
Anti-IZUMO1 antibody used in Western Blot (WB). GTX00746

Cat. No. GTX00746

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, Neutralizing/Inhibition

Reactivity

 Human, Mouse
Package
100 μl ($399)
See all IZUMO1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
ICC/IF 1:100-1:300
IHC-P 1:100
Neutralizing/Inhibition Assay dependent

Note :


It shows the inhibition of sperm fusion with egg.
Not tested in other applications.

Calculated MW

39 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Serum

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

KLH-conjugated synthetic peptides corresponding to the following three regions of human IZUMO1:
[A] C+KSLEKDYLPGHLDA
[B] C+TQVPKEKATDSRQQ
[C] C+ATTESSISLQPLQ

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

izumo sperm-egg fusion 1 , IZUMO , OBF

Cellular Localization

Cell membrane

Background

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]

Database

Research Area

DATA IMAGES

Anti-IZUMO1 antibody used in Western Blot (WB). GTX00746

GTX00746 WB Image

WB analysis of human sperm using GTX00746 IZUMO1 antibody.
Dilution : 1:1000
Loading : 20 μg

Anti-IZUMO1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00746

GTX00746 ICC/IF Image

ICC/IF analysis of human sperms using GTX00746 IZUMO1 antibody.
Lower : Primary antibody
Dilution : 1:100

Anti-IZUMO1 antibody used in IHC (Paraffin sections) (IHC-P). GTX00746

GTX00746 IHC-P Image

IHC-P analysis of mouse testis tissue section using GTX00746 IZUMO1 antibody.
Dilution : 1:100
Antigen retrieval : Proteolytic-Induced Epitope Retrieval

Anti-IZUMO1 antibody used in Western Blot (WB). GTX00746

GTX00746 WB Image

WB analysis of mouse sperm using GTX00746 IZUMO1 antibody.
Dilution : 1:1000
Loading : 10 μg
SDS-PAGE : 10-20% gradient gel

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399