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Integrin alpha 6 antibody [NKI-GoH3]

Anti-Integrin alpha 6 antibody [NKI-GoH3] used in Flow cytometry (FACS). GTX76413
Anti-Integrin alpha 6 antibody [NKI-GoH3] used in Flow cytometry (FACS). GTX76413

Cat. No. GTX76413

Reference 5

Host

 Rat

Clonality

 Monoclonal

Clone Name

 NKI-GoH3

Isotype

 IgG2a

Application

 IHC-Fr, FACS, IP, Blocking, IHC

Reactivity

 Human, Mouse, Dog, Monkey
Package
100 μg ($399)
See all Integrin alpha 6 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Blocking Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

127 kDa. ( Note )

Positive Control

Tonsil

Product Note

human CD49f

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

BALB/c mouse mammary tumour cells

Purification

Purified IgG

Conjugation

Unconjugated

RRID

AB_377329

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin subunit alpha 6 , CD49f , ITGA6B , VLA-6

Cellular Localization

Cell membrane

Background

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Database

Research Area

DATA IMAGES

Anti-Integrin alpha 6 antibody [NKI-GoH3] used in Flow cytometry (FACS). GTX76413

GTX76413 FACS Image

Staining of human peripheral blood platelets with Rat anti Human CD49f:Biotin

Anti-Integrin alpha 6 antibody [NKI-GoH3] used in Flow cytometry (FACS). GTX76413

GTX76413 FACS Image

Staining of human peripheral blood lymphocytes with Rat anti Human CD49f:Biotin

REFERENCE

Application Reference

Zevian S et al. J Biol Chem 2011; 286 (9) : 7496-506 Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated by α3β1 versus α6β4 integrin.
Application : FACS
Reactivity : Human
Sasaki K et al. J Immunother 2009; 32 (8) : 793-802 IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors.
Application : FACS
Reactivity : Mouse
Winterwood NE et al. Mol Biol Cell 2006; 17 (6) : 2707-21 A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5.
Application : Blocking
Reactivity : Human

Clone Reference

Rowland TJ et al. Stem Cells Dev 2010; 19 (8):1231-40 Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin.
Reactivity : Human
Bubier JA et al. J Invest Dermatol 2010; 130 (7):1819-28 A mouse model of generalized non-Herlitz junctional epidermolysis bullosa.
Application : IHC
Reactivity : Mouse
Submit a Reference

REVIEW

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Package List Price ($)
$ 399
Custom Conjugations