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KSHV GPCR antibody

Cat. No. GTX45122

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 FACS

Reactivity

 Kaposi's sarcoma-associated herpesvirus
Package
100 μg ($339)
See all KSHV GPCR products

APPLICATION

Application Note

The use of this product can be used in FACS at an assay dependent dilution, but it has not yet been reported. Optimal dilutions/concentrations should be determined by the end user.

Positive Control

HHV8 GPCR expressed in transfected cells

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Kaposi's sarcoma-associated herpesvirus

Immunogen

Recombinant fragment - amino acids 1-41 of HHV8 GPCR (N-terminal)

Purification

Protein A affinity purified
From polyclonal serum

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Kaposi's sarcoma-associated herpesvirus GPCR , HHV-8 GPCR , Human herpesvirus 8 GPCR

Background

Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8, HHV8), is a gamma herpesvirus that contain an open reading frame encoding a G protein-coupled receptor (GPCR) with putative 7 transmembrane domains. This GPCR has been shown to bind a number of chemokines including IL8, NAP2, PF4, MGSA/Gro alpha, I309, RANTES, MCP1, and MIP1 beta. The receptor is constitutively activated without chemokine binding, and it stimulates cell proliferation. KSHV GPCR is also a viral oncogene that stimulates angio-genesis through induction of VEGF expression. IP10, a chemokine, can inhibit constitutively activated KSHV GPCR.

Research Area

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 339