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Kir6.2 antibody, N-term

Overexpression
Anti-Kir6.2 antibody, N-term used in Flow cytometry (FACS). GTX80493
Anti-Kir6.2 antibody, N-term used in Western Blot (WB). GTX80493
Anti-Kir6.2 antibody, N-term used in Western Blot (WB). GTX80493
Anti-Kir6.2 antibody, N-term used in IHC (Frozen sections) (IHC-Fr). GTX80493

Cat. No. GTX80493

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-Fr, FACS

Reactivity

 Human, Mouse
Package
400 μl ($399)
See all Kir6.2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
IHC-Fr Assay dependent
FACS 1:10-1:50
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

Predict Reactivity

Rabbit(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNJ11.

Purification

Protein A purified, followed by peptide affinity purification.

Conjugation

Unconjugated

RRID

AB_11173060

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

potassium voltage-gated channel subfamily J member 11 , BIR , HHF2 , IKATP , KIR6.2 , MODY13 , PHHI , TNDM3

Cellular Localization

Membrane; Multi-pass membrane protein

Background

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]

Database

Research Area

DATA IMAGES

Anti-Kir6.2 antibody, N-term used in Flow cytometry (FACS). GTX80493

GTX80493 FACS Image

FACS analysis of CEM cells using GTX80493 Kir6.2 antibody, N-term.
Top histogram : negative control
Bottom histogram : CEM cells

Anti-Kir6.2 antibody, N-term used in Western Blot (WB). GTX80493

GTX80493 WB Image

WB analysis of mouse stomach tissue lysate (35ug/lane) using GTX80493 Kir6.2 antibody, N-term.

Anti-Kir6.2 antibody, N-term used in Western Blot (WB). GTX80493

GTX80493 WB Image

Overexpression

The data was published in the journal J Neurotrauma in 2019. PMID: 30160201

Anti-Kir6.2 antibody, N-term used in IHC (Frozen sections) (IHC-Fr). GTX80493

GTX80493 IHC-Fr Image

The data was published in the journal J Neurotrauma in 2019. PMID: 30160201

REFERENCE

Application Reference

Gerzanich V et al. J Neurotrauma 2018; (Epub) SUR1, TRPM4 and KIR6.2 - role in hemorrhagic progression of contusion.
Application : IHC-Fr
Reactivity : Human
Castro L et al. J Neurotrauma 2018; (Epub) Kir6.2, the pore-forming subunit of ATP-sensitive K+ channels, is overexpressed in human post-traumatic brain contusions.
Application : WB
Reactivity : Mouse
Submit a Reference

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399