Form
Liquid
Buffer
PBS, 0.2% BSA
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Human B cell nuclei from plasmacytoid 2p68 cells.
Purification
Purified by ammonium sulfate precipitation.
Conjugation
Unconjugated
RRID
AB_384945
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
CTC75 , FLJ39089 , CTCBF , KARP-1 , G22P1 , KARP1 , KU70 , KU80 , ML8 , KUB2 , TLAA , Ku86 , NFIV , KARP 1
Cellular Localization
Nuclear.
Background
The Ku autoantigen is a heterodimer of 70 kDa (p70) and ~80 kDa (p80) proteins. The p70 / p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Research Area