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Kv11.1 antibody

Anti-Kv11.1 antibody used in Western Blot (WB). GTX54785
Anti-Kv11.1 antibody used in Immunoprecipitation (IP). GTX54785
Anti-Kv11.1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX54785

Cat. No. GTX54785

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IP, IHC

Reactivity

 Human, Mouse, Rat
Package
50 μl ($639)
See all Kv11.1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IP Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

127 kDa. ( Note )

Product Note

The antibody recognizes the HERG1b splice variant but not splice variants HERG1-3 and HERG-4.

Predict Reactivity

Rabbit, Dog(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.025% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.6 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

GST fusion protein with sequence DSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS, corresponding to amino acid residues 1106-1159 (Intracellular, C-terminus) of human Kv11.1 (HERG) (Accession  : Q12809), (MW: 35 kDa.).

Purification

Depleted of anti-GST antibodies by affinity chromatography on immobilized GST and purified by antigen-affinity chromatography.
From serum

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

potassium voltage-gated channel subfamily H member 2 , ERG-1 , ERG1 , H-ERG , HERG , HERG1 , Kv11.1 , LQT2 , SQT1

Cellular Localization

Cell membrane

Background

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Kv11.1 antibody used in Western Blot (WB). GTX54785

GTX54785 WB Image

WB analysis of HEK-293 cell lysates using GTX54785 Kv11.1 antibody preincubated with or without immunogen peptide.
Dilution : 1:400

Anti-Kv11.1 antibody used in Immunoprecipitation (IP). GTX54785

GTX54785 IP Image

IP analysis of HEK-293 cell lysate using GTX54785 Kv11.1 antibody. Red arrow indicates Kv11.1 while the black arrow shows the IgG heavy chain. WB was performed with the GTX54785 antibody.
Lane 1 : Cell lysate
Lane 2 : Lysate + protein A beads + Anti- Kv11.1  Antibody  (GTX54785)
Lane 3 : Cell lysate + protein A beads + Anti-Kv11.1 Antibody (GTX54776)
Lane 4 : Cell lysate + protein A beads + Anti-Kv11.1 Antibody (GTX54789)
Lane 5 : Cell lysate + protein A beads + pre-immune rabbit serum

Anti-Kv11.1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX54785

GTX54785 ICC/IF Image

ICC/IF analysis of HEK-293 transfected  cells using GTX54785 Kv11.1 antibody. Arrows indicate cells that do not express  the channel.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 639