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LAT antibody [LAT-01]

Anti-LAT antibody [LAT-01] used in Flow cytometry (FACS). GTX22852

Cat. No. GTX22852

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 LAT-01

Isotype

 IgG1

Application

 WB, FACS, IP

Reactivity

 Human
Package
100 μg ($399)
See all LAT products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
FACS Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

28 kDa. ( Note )

Product Note

We do not recommend use of this product for Mouse samples.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

LAT , LAT1 , linker for activation of Tcells , pp36 , linker for activation of T cells

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-LAT antibody [LAT-01] used in Flow cytometry (FACS). GTX22852

GTX22852 FACS Image

Flow Cytometry analysis of LAT expression in peripheral blood lymphocytes using anti-human LAT (GTX22852) (surface markers were stained prior to intracellular staining of human LAT).
Panel A: gate on CD4+ cells
Panel B: gate on CD8+ cells

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399