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LATS2 antibody

Anti-LATS2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX87529
Anti-LATS2 antibody used in IHC (Paraffin sections) (IHC-P). GTX87529

Cat. No. GTX87529

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 ICC/IF, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all LATS2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF 1:100~1:500
IHC-P 1:50~1:100
Not tested in other applications.

Calculated MW

120 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human LATS2 (541-590).

Purification

Purified by antigen-affinity chromatography
From serum

Conjugation

Unconjugated

RRID

AB_10723851

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

KPM , LATS2 , large tumor suppressor kinase 2

Cellular Localization

Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Cytoplasm,Cytoplasm,Cytoskeleton,Spindle pole,Nucleus

Background

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-LATS2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX87529

GTX87529 ICC/IF Image

ICC/IF analysis of HepG2 cells using GTX87529 LATS2 antibody. The picture on the right is blocked with the synthesized peptide.

Anti-LATS2 antibody used in IHC (Paraffin sections) (IHC-P). GTX87529

GTX87529 IHC-P Image

IHC-P analysis of human skeletal muscle tissue using GTX87529 LATS2 antibody. The picture on the right is blocked with the synthesized peptide.

REFERENCE

Application Reference

Irie K et al. J Biol Chem 2020; 295 (10) : 3017-3028 Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP.
Zhu L et al. Gene 2020; 742 : 144556
Application : IHC-P
Reactivity : Human
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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399