LI-Cadherin antibody [CDH17/2618]

Cat. No. GTX03259

Host	Mouse
Clonality	Monoclonal
Clone Name	CDH17/2618
Isotype	IgG2b
Application	IHC-P, FACS, Protein Array
Reactivity	Human
Package	100 μg ($459)

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Datasheet

View product citations for antibody GTX03259 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
IHC-P	1-2ug/ml
FACS	1-2μg/million cells
Protein Array	Assay dependent
Note : IHC-P Requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

92 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment (around aa 242-418) of human LI-Cadherin protein (CDH17).

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cadherin 17 , CDH16 , HPT-1 , HPT1

Cellular Localization

Cell membrane

Background

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Database

Gene ID: 1015 CDH17
UniProt: Q12864 CDH17

Research Area

DATA IMAGES

GTX03259 IHC-P Image

IHC-P analysis of human colon tissue using GTX03259 LI-Cadherin antibody [CDH17/2618].

GTX03259 FACS Image

FACS analysis of MCF-7 cells using GTX03259 LI-Cadherin antibody [CDH17/2618].
Blue : Primary antibody
Red : Isotype control

GTX03259 Protein Array Image

The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

REFERENCE

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REVIEW

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Package

List Price ($)

100 μg

$ 459

Qty