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Lamin A antibody [4E7]

Anti-Lamin A antibody [4E7] used in IHC (Paraffin sections) (IHC-P). GTX60478
Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478
Anti-Lamin A antibody [4E7] used in ELISA (ELISA). GTX60478
Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478

Cat. No. GTX60478

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4E7

Isotype

 IgG1

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μl ($409)
See all Lamin A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1/500 - 1/2000
IHC-P 1/200 - 1/1000
ELISA 1/10000
Not tested in other applications.

Calculated MW

74 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

0.03% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Purified recombinant fragment of human LMNA expressed in E. Coli.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lamin A/C , CDCD1 , CDDC , CMD1A , CMT2B1 , EMD2 , FPL , FPLD , FPLD2 , HGPS , IDC , LDP1 , LFP , LGMD1B , LMN1 , LMNC , LMNL1 , MADA , PRO1

Cellular Localization

Nucleus,nucleoplasm

Background

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

Database

Research Area

DATA IMAGES

Anti-Lamin A antibody [4E7] used in IHC (Paraffin sections) (IHC-P). GTX60478

GTX60478 IHC-P Image

IHC-P analysis of human striated muscle tissue using GTX60478 Lamin A antibody [4E7].

Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478

GTX60478 WB Image

WB analysis of Raw264.7 (1), PC-12 (2), THP-1 (3), A431 (4), MCF-7 (5) and Jurkat (6) cell lysate using GTX60478 Lamin A antibody [4E7].

Anti-Lamin A antibody [4E7] used in ELISA (ELISA). GTX60478

GTX60478 ELISA Image

ELISA analysis of antigen using GTX60478 Lamin A antibody [4E7].
Red : Control antigen 100ng
Purple : Antigen 10ng
Green : Antigen 50ng
Blue : Antigen 100ng

Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478

GTX60478 WB Image

WB analysis of human LMNA (AA: 212-477) recombinant protein using GTX60478 Lamin A antibody [4E7].

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 409