MEK1 (phospho Ser217) antibody

Cat. No. GTX79015

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	IHC-P
Reactivity	Human
Package	100 μg ($399)

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Datasheet

View product citations for antibody GTX79015 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
IHC-P	1:50 - 1:100

Not tested in other applications.

Calculated MW

43 kDa. ( Note )

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human MEK1 around the phosphorylation site of serine 217 (I-D-Sp-M-A).

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

RRID

AB_11167599

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CFC3,MAP2K1,MAPKK1,MEK1,MKK1,PRKMK1,mitogenactivated protein kinase kinase 1,mitogen-activated protein kinase kinase 1

Cellular Localization

Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Spindle pole body,Nucleus,Membrane

Background

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

Database

Gene ID: 5604 MAP2K1
UniProt: Q02750 MAP2K1

Research Area

DATA IMAGES

GTX79015 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX79015 MEK1 (phospho Ser217) antibody.

REFERENCE

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REVIEW

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Package

List Price ($)

100 μg

$ 399

Qty